This indicates an attack attempt against a remote code-execution vulnerability in Microsoft Office Excel.
The vulnerability is caused by an error when the vulnerable software handles a specially crafted .XLS file. It allows a remote attacker to execute arbitrary code.
Microsoft Office Excel 2002 Service Pack 3
Microsoft Office Excel 2003 Service Pack 3
Microsoft Office Excel 2007 Service Pack 1
Microsoft Office Excel 2007 Service Pack 2
System Compromise: Remote attackers can gain control of vulnerable systems.
Apply the patch, available from the vendor's web site: