This indicates an attack attempt to exploit a Remote Code Execution vulnerability in Trend Micro Smart Protection Server.
The vulnerability is due to an error when the vulnerable software attempts to handle a maliciously crafted user input. An attacker can exploit this to execute arbitrary code within the context of the target application, via a crafted request.
Trend Micro Smart Protection Server Version 2.5
Trend Micro Smart Protection Server Version 2.6
Trend Micro Smart Protection Server Version 3.0
System Compromise: Remote attackers can execute arbitrary code within the context of the target system.
Apply the latest patch from the vendor.