This indicates an attack attempt against multiple vulnerabilities in McAfee ePolicy Orchestrator.
The vulnerabilities are caused by buffer-overflow errors in the "SiteManager.dll" ActiveX control. It may allow a remote attacker to execute arbitrary code by enticing users into visiting a specially crafted web page.
McAfee ePolicy Orchestrator (ePO) versions 3.x
McAfee ProtectionPilot versions 1.x
Apply the patches supplied by the vendor: